Intensive Lifestyle Intervention in Type 2 Diabetes
Weight loss is recommended for overweight or obese patients with type 2 diabetes on the basis of short-term studies, but long-term effects on cardiovascular disease remain unknown. This study examined whether an intensive lifestyle intervention for weight loss would decrease cardiovascular morbidity and mortality among such patients.
In 16 study centers in the United States, researchers randomly assigned approximately 5000 obese patients with type 2 diabetes to participate in an intensive lifestyle program that promoted weight loss through decreased caloric intake and increased physical activity 1 or to receive diabetes support and education 2. The researchers then followed both groups over a period of maximum 13.5 years to see how they compared on number of deaths from cardiovascular causes, nonfatal myocardial infarction 3, nonfatal stroke or hospitalization for pain.
Naturally, weight loss was greater in the intervention group than in the control group throughout the study. The intensive lifestyle intervention also produced greater reductions in glycated hemoglobin 4 and greater initial improvements in fitness and all cardiovascular risk factors, except for low-density-lipoprotein cholesterol levels.
What do we want to know?
Would an intensive lifestyle intervention designed to achieve weight loss through caloric restriction and increased physical activity decrease cardiovascular morbidity and mortality among overweight or obese adults with type 2 diabetes?
What is the research about?
Researchers took overweight or obese adults with diabetes type 2 and researched whether those people have a decreased cardiovascular morbidity and mortality if they undergo an intensive lifestyle intervention( to achieve weight loss through caloric restriction and increased physical activity.
What does the article tell us and what does this mean?
The study was published in 2013 and showed that an intensive lifestyle intervention did not reduce the risk of cardiovascular morbidity or mortality, as compared with a control program of diabetes support and education, among overweight or obese patients with type 2 diabetes.
Source: N Engl J Med 2013; 369:145-154